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Today I had the Covid 19 vaccine. I am in the people who are clinically extremely vulnerable list. I am on immunosuppression drugs due to my rheumatoid arthritis condition. I was called by my local doctors surgery previously to go down and have it. But having an illness with a high temperature. The offer was then refused. The next day, I again was offered to be put on the contingency list for the next two days that the vaccine was being administered. I was told I have to be down there within ten minutes of the call. Thankfully with my husband working from home, he was able to just stop work and drive me down and wait for me. Remember I have to use two crutches. All so my surgery is just over half a mile work from my home. I had the AstraZeneca vaccine.
The AstraZeneca COVID-19 vaccine uses a replication deficient chimpanzee adenovirus as a vector that encodes the full-length SARS-CoV2 spike protein. Chimpanzee adenoviruses are non-enveloped viruses, meaning that the glycoprotein antigen is not present on the surface of the vector, but is only expressed at high levels once the vector enters the target cells. Genes are deleted from the adenovirus to render the virus replication incompetent, and to enhance immunogenicity. Once the vector is in the nucleus, mRNA encoding the spike protein is produced that then enters the cytoplasm. This leads to translation of the target protein which acts as an intracellular antigen. Data from vaccine trials undertaken indicate high vaccine efficacy, with no serious safety events related to the vaccine.
I am due my second Covid 19 vaccine within the next twelve weeks. I am apprehensive if this will actually work for me. I have had to shield and stay home for over nine months so far. And not see my family or friends except through my phone. Now I have to wait for everyone else to get their dose and have a normal new life. Time will tell !